false positive cologuard

HaC 2025

3 min read 18-03-2025

Meta Description: Worried about a Cologuard false positive? This comprehensive guide explains what causes them, how common they are, and what to expect during follow-up procedures. Learn how to manage your anxiety and navigate the next steps with confidence. Get the facts and reassurance you need about your Cologuard results. (157 characters)

What is Cologuard?

Cologuard is a non-invasive at-home colorectal cancer screening test. It detects the presence of DNA and blood in a stool sample. This helps identify the potential presence of cancerous or precancerous polyps in the colon. While highly effective, it's crucial to understand that like any screening test, Cologuard can produce false positive results.

What is a False Positive Cologuard Result?

A false positive Cologuard result means the test indicates a potential problem when, in reality, there's no cancerous or precancerous polyp. This doesn't mean the test is unreliable; rather, it highlights the test's sensitivity. It's designed to detect even minute signs that might warrant further investigation.

While inconvenient, a false positive is preferable to a false negative, where cancer is missed. The aim is to err on the side of caution. Further tests will be needed to rule out any genuine issues.

How Common Are False Positives with Cologuard?

The rate of false positives with Cologuard varies depending on several factors. These include the individual's age, overall health, and the presence of other underlying conditions. Studies show the false positive rate to be between 10-15%. This means that for every 100 people tested, 10-15 might receive a false positive result.

Factors that can increase the risk of a false positive Cologuard result include:

Recent Colonoscopy: Recent procedures can sometimes lead to temporary inflammation that can trigger a positive result.
Diet: A diet high in red meat or processed foods can sometimes affect the test's results.
Medications: Certain medications might interfere with the accuracy of the test.
Inflammatory Bowel Disease (IBD): Conditions like Crohn's disease or ulcerative colitis can trigger positive results.

What Happens After a False Positive Cologuard Result?

Receiving a false positive can be anxiety-inducing. However, it's important to remember that further investigation is necessary to confirm the findings. Your doctor will likely recommend a colonoscopy.

A colonoscopy is a more invasive procedure, but it allows for a direct visual examination of the colon and the ability to remove any polyps found during the exam. It's the gold standard for colorectal cancer screening.

How to Manage Anxiety After a False Positive Cologuard Result:

Talk to your doctor: Discuss your concerns and ask questions. Understanding the process can alleviate anxiety.
Connect with others: Share your experience with friends, family, or support groups. Knowing you're not alone can be helpful.
Practice self-care: Engage in activities that promote relaxation, like exercise, meditation, or spending time in nature.
Avoid self-diagnosing: Focus on the next steps and trust the medical professionals guiding you.

What Should I Expect During a Follow-up Colonoscopy?

A colonoscopy involves inserting a thin, flexible tube with a camera into your rectum to examine the colon. Before the procedure, you'll need to follow a bowel preparation regimen to clear your bowels. The procedure is typically performed under sedation, making it relatively painless.

During the colonoscopy, the doctor will be able to directly visualize the colon lining and remove any abnormal growths for further testing. This provides a definitive diagnosis, effectively ruling out cancer.

Conclusion:

Receiving a false positive Cologuard result is a common occurrence. While concerning, it is crucial to remember that further investigation is necessary to determine the true status of your health. A colonoscopy is an effective way of confirming the results and is often needed to rule out cancerous or precancerous growths. By understanding the process, managing anxiety, and staying connected with your healthcare provider, you can navigate this experience with greater confidence. Remember to discuss any concerns you have with your doctor promptly. A timely follow up ensures your health is properly addressed and any issues are resolved effectively.